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dr hab. Barbara Błasiak, prof. IFJ PAN (Instytut Fizyki Jądrowej PAN, Kraków, Polska)

Termin: 04.02.2020

Tytuł referatu:
"Molecular Magnetic Resonance Imaging of Cancer using Core/Shell Nanoparticles"

Zapraszamy na seminarium, które odbędzie się w dniu 4 lutego 2020 r. (wtorek) o godz. 16.15 w sali A-1-08. Prelegent: dr hab. Barbara Błasiak, prof. IFJ PAN. Temat seminarium: "Molecular Magnetic Resonance Imaging of Cancer using Core/Shell Nanoparticles".

Curriculum vitae prelegenta

Announcement about the seminar


Magnetic Resonance Imaging (MRI) has been used for early cancer detection, treatment monitoring and image guided surgery. MRI has excellent spatial resolution and soft tissue contrast but low specificity. Standard contrast enhanced MRI based on tumors vasculature, including Gd-based T1 contrast agents, does not provide sufficiently high specificity for tumor diagnosis and thus contrast agents providing T2 contrast have been applied to provide information on tumor specificity. To improve the tumor contrast we have developed core/shell NaDyF4/NaGdF4 nanoparticles changing both T1 and T2 relaxation times of surrounding water molecules and conjugated them with tumor specific antibodies. The relaxation times (T1 and T2) of the nanoparticles with various score/shell sizes and concentrations were measured at 9.4T and 3T to find the optimum T1/T2 ratio for MRI. T1- and T2-weighted images using core/shell nanoparticles of the animal models of brain, breast and prostate cancer were collected and combined to provide enhanced contrast and edges.


Data opublikowania: 20.01.2020
Osoba publikująca: Tomasz Malarz